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We are asking to help in an important initiative that could shape the future of clinical practice. The VPH Institute, the International Society for In Silico Medicine, is conducting a global survey to better understand clinicians' knowledge, experiences, and opinions about the use of Computer Modelling and Simulation in healthcare. This is a critical step towards understanding and improving how these cutting-edge tools are applied in daily medical practice.

Dear all,

We will soon conclude UNICA4EU project, a groundbreaking EU funded project that bridges the realms of pediatric cancer and AI research. Our research has set the fundaments for further development in the following objectives:

-        Established a framework for upscaling AI in pediatric cancer for the next decade.

-        Co-designed an EU-wide methodology for secure AI-based interventions.

-        Advocated for policies prioritizing patient rights and AI adoption in healthcare.

Backed by 15 partners across 8 European countries, and prestigious entities like SIOP Europe, we're at the forefront of this intersection.

Given your expertise in the field we invite you to read more about our project here.

Thanks for your support!

To find more about UNICA4EU you can visit our website: https://unica4.eu/

A supplemental issue of Pediatric Blood & Cancer is now online about Pediatric Renal Tumors - A HARMONICA Initiative:

Pediatric Renal Tumors - A HARMONICA Initiative PBC 70 (S2) 2023 ->A Supplemental Issue with an Editorial and 10 Renal Tumor Papers

The COVID-19 pandemic is one of the most serious global challenges to delivering affordable and equitable treatment to children with cancer we have witnessed in the last few decades. This Special Report aims to summarise general principles for continuing multi-disciplinary care during the SARS-CoV-2 (COVID-19) pandemic. With contributions from the leadership of the International Society for Paediatric Oncology (SIOP), Children’s Oncology Group (COG), St Jude Global programme and Childhood Cancer International, we have sought to provide a framework for healthcare teams caring for children with cancer during the pandemic. We anticipate the burden will fall particularly heavily on children, their families and cancer services in low- and middleincome countries. Therefore, we have brought together the relevant clinical leads from SIOPEurope, COG and SIOP-PODC (Pediatric Oncology in Developing Countries) to focus on the six most curable cancers that are part of the WHO Global Initiative in Childhood Cancer. We provide some practical advice for adapting diagnostic and treatment protocols for children with cancer during the pandemic, the measures taken to contain it (e.g. extreme social distancing) and how to prepare for the anticipated recovery period.

The paper can be found here.

Wilms Tumour:

Wilms Tumor (WT) or nephroblastoma is a highly curable childhood cancer with cure rates around 90% as shown by the SIOP Renal Tumour Study Group (SIOP-RTSG) and the Children’s Oncology Group (COG) (1). During the last decades treatment is stratified according to clinical (SIOP and COG) and molecular risk factors (COG) to avoid under- and overtreatment. This resulted in curing patients by minimizing acute toxicities and late effects and in avoiding as many relapses as possible. To provide this standard of care will be a specific challenge during the COVID-19 pandemic as the ability to deliver adequate diagnosis, treatment and supportive care for patients with WT will vary from country to country and even from region to region depending on the overload of the health care system caused by COVID-19.

The VPHi members, Prof Norbert Graf and Prof Georgios Stamatakos, have joined forces to validate the Nephroblastoma Oncosimulator and design the next critical steps of its clinical translation procedure.

Cancer has been designated as one of the key research and innovation missions of the next framework programme Horizon Europe (2021-2027). These missions are high-ambition, high profile initiatives, to find solutions to some of the major challenges faced by European citizens, with a clear target that captures the imagination of citizens at large.

The researchers analysed the records of 548 children with a suspected kidney cancer treated in the UK and Republic of Ireland who took part in an international clinical trial (SIOP WT 2001) between 2002-2011. During this trial, all children in the UK/ROI were recommended to have a biopsy before starting chemotherapy. In other countries, chemotherapy is usually started without a biopsy since nine times out of ten, a kidney tumour in a young child is a type of cancer called Wilms tumour and the diagnosis is confirmed when the affected kidney is removed 4-6 weeks later. Giving chemotherapy before surgery to remove a kidney affected by Wilms tumour makes surgery less risky. However, chemotherapy is not needed for some non-Wilms tumours.

On the basis of the results of previous national and international trials and studies, the Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new study protocol for paediatric renal tumours: the UMBRELLA SIOP-RTSG 2016 protocol (the UMBRELLA protocol). Currently, the overall outcomes of patients with Wilms tumour are excellent, but subgroups with poor prognosis and increased relapse rates still exist. The identification of these subgroups is of utmost importance to improve treatment stratification, which might lead to reduction of the direct and late effects of chemotherapy.