In silico oncology en route to clinical translation

The VPHi members, Prof Norbert Graf and Prof Georgios Stamatakos, have joined forces to validate the Nephroblastoma Oncosimulator and design the next critical steps of its clinical translation procedure.

Cancer has been designated as one of the key research and innovation missions of the next framework programme Horizon Europe (2021-2027). These missions are high-ambition, high profile initiatives, to find solutions to some of the major challenges faced by European citizens, with a clear target that captures the imagination of citizens at large.

Experts in kidney cancer from the Children’s Cancer and Leukaemia Group have published a new recommendation on when a biopsy of the suspected tumour should be taken

The researchers analysed the records of 548 children with a suspected kidney cancer treated in the UK and Republic of Ireland who took part in an international clinical trial (SIOP WT 2001) between 2002-2011. During this trial, all children in the UK/ROI were recommended to have a biopsy before starting chemotherapy. In other countries, chemotherapy is usually started without a biopsy since nine times out of ten, a kidney tumour in a young child is a type of cancer called Wilms tumour and the diagnosis is confirmed when the affected kidney is removed 4-6 weeks later. Giving chemotherapy before surgery to remove a kidney affected by Wilms tumour makes surgery less risky. However, chemotherapy is not needed for some non-Wilms tumours.

The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol

On the basis of the results of previous national and international trials and studies, the Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new study protocol for paediatric renal tumours: the UMBRELLA SIOP-RTSG 2016 protocol (the UMBRELLA protocol). Currently, the overall outcomes of patients with Wilms tumour are excellent, but subgroups with poor prognosis and increased relapse rates still exist. The identification of these subgroups is of utmost importance to improve treatment stratification, which might lead to reduction of the direct and late effects of chemotherapy.

Genomics offers new treatment options for infants with range of soft tissue tumors

The genetic causes of a group of related infant cancers have been discovered by scientists at the Wellcome Sanger Institute, the University of Wuerzburg and their collaborators. Whole genome sequencing of tumours revealed mutations which are targetable by existing drugs used to treat lung cancer and melanoma. The results, published today (18 June) in Nature Communications have implications for clinical practice and the diagnosis of rare cancers in infants, and could lead to new, targeted treatment options for these children.

Study shows a new approach to treating patients with stage IV Wilms tumor

A new study showing significantly improved survival rates for patients with stage IV Wilms tumors with lung metastases was recently published in the Journal of Clinical Oncology. The outcomes of the study, "Treatment of Stage IV Favorable Histology Wilms Tumor With Lung Metastases: A Report From the Children's Oncology Group AREN0533 Study", will be a game-changer in treating Wilms tumor and reduce the need for radiation - and the long-term risks associated with it - in nearly half of patients whose cancer has spread to the lung.

Childhood cancer survivors living longer but do not report improvement in health status

Long-term survivors of childhood cancer live longer thanks to improvements to cancer treatments, but a new study looking at three decades of therapy suggests patients do not report better health status. The findings from the Childhood Cancer Survivor Study (CCSS), which include feedback from a survey of more than 14,000 adult survivors treated from 1970 to 1999, appear online in Annals of Internal Medicine.

USC researchers discover a key difference between mouse and human kidney cells

The best laid plans of mice and men are a bit different - at least when it comes to kidney development. Compared to a mouse, a human has nearly 100 times more nephrons, the functional units of the kidneys. Humans may owe these abundant nephrons to a gene called SIX1, according to a new paper published in the journal Development.

UK diagnoses children's kidney cancer at a later stage than Germany

THE UK diagnoses Wilms' tumours - the most common children's kidney cancer - when they are larger and more advanced compared with those diagnosed in Germany, according to a Cancer Research UK-funded study* published in the journal Archives of Disease in Childhood, today (Monday). Researchers from University College London (UCL), Newcastle University, Great Ormond Street Hospital for Children, the Netherlands Cancer Institute and University Hospital Homburg, Germany compared statistics for more than 1,500 children diagnosed with Wilms' tumour and treated in the UK and Germany between 2002 and 2011. This included 616 children in the UK and 951 in Germany.

Large differences in cancer survival between European countries still remain despite major improvements in cancer diagnosis and treatment

Cancer survival still varies widely between European countries despite major improvements in cancer diagnosis and treatment during the first decade of the 21st century, according to the latest EUROCARE-5 reports covering over 50% of the adult and 77% of the childhood population of Europe. The findings, published in The Lancet Oncology, analysed data from cancer registries covering all or part of 29 countries* to compare 5-year survival from diagnosis for more than 9 million adults and 60 415 children diagnosed between 2000 and 2007.

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